Functional gradient scaffolds capable of dual drug spatiotemporal release

4 March 2016
Yuanyuan Liu, Hongchen Yu, Yi Liu, Gang Liang, Ting Zhang, and Qingxi Hu
A novel 3D bio-printing platform is integrated with a forming system that combines electrospinning and extrusion deposition to prepare drug-loaded structures.
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Authors

Yuanyuan Liu
Shanghai University

Hongchen Yu
Shanghai University

Yi Liu
Shanghai University

Gang Liang
Shanghai University

Ting Zhang
Shanghai University

Qingxi Hu
Shanghai University


References

  1. N. Mohan, N. H. Dormer, K. L. Caldwell, V. H. Key, C. J. Berkland and M. S. Detamore, Continuous gradients of material composition and growth factors for effective regeneration of the osteochondral interface, Tissue Eng. Part A 17, pp. 2845-2855, 2011.

  2. A. Seidi, M. Ramalingam, I. Elloumi-Hannachi, S. Ostrovidov and A. Khademhosseini, Gradient biomaterials for soft-to-hard interface tissue engineering, Acta Biomater. 7, pp. 1441-1451, 2011.

  3. S. Samavedi, S. A. Guelcher, A. S. Goldstein and A. R. Whittington, Response of bone marrow stromal cells to graded co-electrospun scaffolds and its implications for engineering the ligament-bone interface, Biomaterials 33, pp. 7727-7735, 2012.

  4. N. H. Dormer, M. Singh, L. Wang, C. J. Berkland and M. S. Detamore, Osteochondral interface tissue engineering using macroscopic gradients of bioactive signals, Ann. Biomed. Eng. 38, pp. 2167-2182, 2010.

  5. C. Vaquette, W. Fan, Y. Xiao, S. Hamlet, D. W. Hutmacher and S. Ivanovski, A biphasic scaffold design combined with cell sheet technology for simultaneous regeneration of alveolar bone/periodontal ligament complex, Biomaterials 33, pp. 5560-5573, 2012.

  6. S. A. Park, H. J. Kim, S. H. Lee, J. H. Lee, H. K. Kim, T. R. Yoon and W. D. Kim, Fabrication of nano/microfiber scaffolds using a combination of rapid prototyping and electrospinning systems, Polym. Eng. Sci. 51, pp. 1883-1890, 2011.

  7. Y.-Z. Yu, L.-L. Zheng, H.-P. Chen, W.-H. Chen and Q.-X. Hu, Fabrication of hierarchical polycaprolactone/gel scaffolds via combined 3D bioprinting and electrospinning for tissue engineering, Adv. Manufact. 2, pp. 231-238, 2014.

  8. F. Yan, Y. Liu, H. Chen, F. Zhang, L. Zheng and Q. Hu, A multi-scale controlled tissue engineering scaffold prepared by 3D printing and NFES technology, AIP Adv. 4, pp. 031321, 2014.

  9. H. J. Lee and W. G. Koh, Hydrogel micropattern-incorporated fibrous scaffolds capable of sequential growth factor delivery for enhanced osteogenesis of hMSCs, ACS Appl. Mater. Interfaces 6, pp. 9338-9348, 2014.

  10. D. Suárez-González, J. S. Lee, A. Diggs, Y. Lu, B. Nemke, M. Markel, S. J. Hollister and W. L. Murphy, Controlled multiple growth factor delivery from bone tissue engineering scaffolds via designed affinity, Tiss. Eng. Part A 20, pp. 2077-2087, 2014.

  11. Y.-Y. Liu, H.-C. Yu, Y. Liu, G. Liang, T. Zhang and Q.-X. Hu, Dual drug spatiotemporal release from functional gradient scaffolds prepared using 3D bioprinting and electrospinning, Polym. Eng. Sci. 56, pp. 170-177, 2016.

  12. X. Shen, C. Wan, G. Ramaswamy, M. Mavalli, Y. Wang, C. L. Duvall, L. F. Deng, R. E. Guldberg, A. Eberhart, T. L. Clemens and S. R. Gilbert, Prolyl hydroxylase inhibitors increase neoangiogenesis and callus formation following femur fracture in mice, J. Orthopaed. Res. 27, pp. 1298-1305, 2009.

  13. C. Wan, S. R. Gilbert, Y. Wang, X. Cao, X. Shen, G. Ramaswamy and K. A. Jacobsen, Activation of the hypoxia-inducible factor-1α pathway accelerates bone regeneration, Proc. Nat'l Acad. Sci. USA 105, pp. 686-691, 2008.

  14. Y.-H. Kim and Y. Tabata, Dual-controlled release system of drugs for bone regeneration, Adv. Drug. Deliv. Rev. 94, pp. 28-40, 2015.

  15. J. Min, R. D. Braatz and P. T. Hammond, Tunable staged release of therapeutics from layer-by-layer coatings with clay interlayer barrier, Biomaterials 35, pp. 2507-2517, 2014.

DOI:  10.2417/spepro.006372



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